Microsoft Office 365 is commercial Software+Service cloud based product, while Office 2010 is the desktop application version of Microsoft Office. Therefore you don’t need to worry about the risks of maintaining different versions of Office in multiple computers and not properly synching with Office 365. Microsoft Office Professional Plus version is now available as a subscription based service with Office 365 (customers had to pay for it all at once earlier with 2010). However, Office Web Apps (of 365) do not have all the capabilities of the full versions (which come with 2010), plus not all components of Office 2010 are available with 365. But, since high speed internet connections are not available everywhere, Office 2010 will be better for data intensive operations compared to Office 365.
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