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The best way to fix this is to uninstall Hijackthis from the add or remove programs (programs and features in windows vista and windows 7) and then re-install it.

You can get it from here :

http://download.cnet.com/Trend-Micro-HijackThis/3000-8022_4-10227353.html

Here’s to Good Karma

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There can be malware prevailing in your system. Due to this malware hijackthis file got corrupted. You can run anti-malwware program on computer and delete malware detected. Check for hijackthis file in running processes by opening Task Manager. Try to end the task. If it ends up easily then its fine otherwise download spyware fix software.